In some small studies, tapentadol (Nucynota) and oxycodone have been shown to cause less constipation than other opioids. Research also shows that fentanyl patches may not cause constipation at the same rate as other opioid medications. Medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and antidepressants, can cause constipation. Laxatives can help treat the effects of constipation caused by these medications.
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